oncomine brca

30/10/2019 · The Oncomine BRCA Research Assay uniquely empowers laboratories to detect all classes of mutations in one NGS workflow, removing the need to employ multiple technologies. Learn how the Oncomine BRCA Research Assay offers sensitive, specific detection of

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Kit contents and storage The Oncomine BRCA Research Assay (Cat. No. A32840) is a bundle of the Oncomine BRCA Research Assay Manual Library Preparation panel and the Ion AmpliSeq Library Kit Plus, sufficient for manually preparing 24 libraries.

24/9/2019 · The Oncomine BRCA Research Assay uniquely empowers laboratories to detect all classes of mutations in one NGS workflow, removing the need to employ multiple technologies. Learn how the Oncomine BRCA Research Assay offers sensitive, specific detection of

1/11/2019 · The Oncomine BRCA Research Assay consists of two pools of AmpliSeq oligonucleotide primers and associated reagents to generate amplicon libraries for next-generation sequencing (NGS) on Ion Torrent platforms. The assay is designed to provide sensitive and

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Oncomine BRCA Research Assay Catalog Number A32840 Pub. No. MAN0015994 Rev. B.0 Note: For safety and biohazard guidelines, see the “Safety” appendix in the Oncomine BRCA Research Assay User Guide (Pub. No. MAN0014634). Read the Safety

Oncomine BRCA Research Assay Variant type Oncomine Gene class Oncomine Variant class Annotation criteria Copy number deletion Loss-of-Function Deletion SVTYPE = “CNV” FILTER = “LOSS”, SUBTYPE = “GeneCNV

Oncomine Brca1 2 Panel, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 95/100, based on 2 PubMed citations. ZERO BIAS – scores, article reviews, protocol conditions and more Home > Search Results > Thermo Fisher >

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Oncomine BRCA Research Assay. We used this combined set of 11 runs to evaluate our candidate algorithms, and the results are presented in Table 1. Table 1. Detecting large indels, and exon or gene deletions or duplications in BRCA1 and BRCA2.

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WHITE PAPER Oncomine BRCA Research Assay Evaluation of the Oncomine BRCA Research Assay for variant detection by next-generation sequencing Summary • BRCA1 and BRCA2 (BRCA1/2) are human genes that play an important role in DNA repair.

BRCA stands for BReast CAncer susceptibility gene. Normally, BRCA genes work to suppress tumors from growing. But when these genes are mutated, they are no longer able to help suppress tumors, leading to an increased risk of cancer. Mutations in the

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Oncomine BRCA Research Assay. We used this combined set of 11 runs to evaluate our candidate algorithms, and the results are presented in Table 1. Table 1. Detecting large indels, and exon or gene deletions or duplications in BRCA1 and BRCA2.

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WHITE PAPER Oncomine BRCA Research Assay Evaluation of the Oncomine BRCA Research Assay for variant detection by next-generation sequencing Summary • BRCA1 and BRCA2 (BRCA1/2) are human genes that play an important role in DNA repair.

BRCA stands for BReast CAncer susceptibility gene. Normally, BRCA genes work to suppress tumors from growing. But when these genes are mutated, they are no longer able to help suppress tumors, leading to an increased risk of cancer. Mutations in the

Significant allelic dropout phenomenon of Oncomine BRCA Research Assay on Ion Torrent S5 Evaluation of immature platelet fraction in patients with myelodysplastic syndromes. Association with poor prognosis factors Influence of temperature of transport of

TY – JOUR T1 – Significant allelic dropout phenomenon of oncomine BRCA research assay on ion torrent S5 AU – Jeong, Tae Dong AU – Cho, Sung-Yup AU – Kim, Mi Wha AU – Huh, Jungwon PY – 2019/6/1 Y1 – 2019/6/1 KW – Oncomine BRCA Research

Outsourced testing can cost more due to third-party margins, leading to higher healthcare costs overall, regardless of payer. In-house testing can help reduce cost to the healthcare system and patients with the right NGS test. The Oncomine Dx Target Test is

BRCA mutations are often germline, meaning they are in all cells in your body and may be passed down to your children. If there is a family history of ovarian cancer, or BRCA mutations, this can increase your risk of developing ovarian and breast cancer.

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Ion AmpliSeq BRCA1 and BRCA2 Panel A community panel designed with input from leading researchers The Ion AmpliSeq BRCA1 and BRCA2 Panel contains primer pairs that target the coding regions of the tumor suppressor genes BRCA1 and BRCA2, which

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omicOnen BRCA Research Assay Now with a new feature—large InDel & exon/gene deletion/duplication detection algorithms The Ion Torrent Oncomine BRCA Research Assay for the detection of BRCA somatic and germline mutations from formalin-fixed

8/2/2019 · A companion diagnostic device can be in vitro diagnostic device or an imaging tool that provides information that is essential for the safe and effective use of a corresponding therapeutic product. The use of an IVD companion diagnostic device with a

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Ion AmpliSeq BRCA1 and BRCA2 Panel A community panel designed with input from leading researchers The Ion AmpliSeq BRCA1 and BRCA2 Panel contains primer pairs that target the coding regions of the tumor suppressor genes BRCA1 and BRCA2, which

The Oncomine Dx Target Test is the first targeted next-generation sequencing (NGS) in vitro diagnostic test, which can analyze all key biomarkers for EGFR, ALK, BRAF, ROS1 kinase inhibitors, and many more currently in clinical trials • The tissue input

Oncomine BRCA Research Assay Oncomine Breast cfDNA Assay Oncomine Breast cfDNA Research Assay v2 Oncomine Childhood Cancer Research Assay Oncomine Colon cfDNA Assay Oncomine Comprehensive Assay Oncomine Comprehensive Assay v3

can view a BRCA Report that shows read counts of BRCA1 and BRCA2 exons that are normalized to the Oncomine BRCA DNA Baseline. In the IRGV tab, you can view exon deletions or duplications on chromosomes 13 and 17. Click to open the

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Oncomine Fusion Panel RNA (Fusion, 4 Gene): ALK, NTRK1, RET, ROS1 CE‐IVD Oncomine Fusion Panel (Rearrangement von ALK, ROS1, RET und NTRK1 mit korrespondierenden Partnern, Exone in Klammern, Analyse auf RNA Ebene

9/11/2016 · New Oncomine products enable immune response analysis of the tumor microenvironment, interrogation of BRCA 1-2 genes, and liquid biopsy research using cell-free DNA from breast and colon cancer samples November 09, 2016 08:00 AM Eastern

Ovarian cancer is the eighth most common cancer affecting women in Australia. [1] There are three types of ovarian cancer: Epithelial tumours which are the most common type (account for about 90% of ovarian cancers) and is cancer that starts in the cells lining in

More Summary: The Oncomine BRCA Research Assay uniquely empowers laboratories to detect all classes of mutations ( SNVs, InDels, and large exon/gene deletions/duplications) in one NGS workflow, removing the need to employ multiple technologies. The

amplified the target with the Oncomine BRCA Research Assay and sequenced on Ion Torrent S5 XL (Thermo Fisher Scientific, Waltham, MA, USA). We compared two bioinformatics pipelines for optimal processing of S5 XL sequence data: the Torrent

8/3/2019 · Our laboratory was first to show involvement of CC chemokines in BrCa. In this study, using ONCOMINE, TCGA, bc-GenExMiner and KMplotter, we examined the association of CC chemokines in BrCa outcomes and disparity. We show over-expression of -17

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amplification, we amplified the target with the Oncomine BRCA Research Assay and sequenced on Ion Torrent S5 XL (Thermo Fisher Scientific, Waltham, MA, USA). We compared two bioinformatics pipelines for optimal processing of S5 XL sequence data:

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Report template Oncomine Knowledgebase Reporter templates are flexible to let you add a logo, location, operator, and other custom fields to quickly create tailored, lab-generated reports. Global clinical trials For each gene variant, a summaryThermo Fisher

A previous study has already reported that the Oncomine BRCA Research Assay showed 99.85% sensitivity, 100% specificity, 0% false-positive rate and 99.99% accuracy in detecting single nucleotide variations (SNVs) and small deletions [2], indicating

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panel (OncoMine Comprehensive Assay) coupled with high-throughput sequencing using Ion Proton sequencer for routine screening of solid tumors. The panel screens 143 genes using low amounts of formalin- fixed, paraf n-embedded DNA (20 ng) and RNA (10

30/11/2018 · The library for NGS was prepared manually with 10 ng of the isolated DNA using Oncomine BRCA assay – A328400 (Thermo Fisher Scientific), containing 265 primer pairs for 100% exonic coverage with large intronic flanking regions of BRCA1 and BRCA2

位置: 8600 Rockville Pike, Bethesda, MD
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APPLICATION NOTE Oncomine Lung cfDNA Assay and Ion S5 XL System Ne xt-generation sequencing analysis of low-frequency mutations from cell-free DNA Key findings • Perform targeted next-generation sequencing (NGS) analysis from cell-free DNA (cfDNA

This filter can be added to filter chains in Ion Reporter Software to detect variants that match those in specific Oncomine panels, including: Oncomine BRCA DNA Regions Oncomine Breast cfDNA Regions Oncomine Colon cfDNA Regions Oncomine

The Oncomine BRCA Research Assay uniquely empowers laboratories to detect all classes of mutations ( SNVs, InDels, and large exon/gene deletions/duplications) in one NGS workflow, removing the need to employ multiple technologies.

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Gene Expression Panel, Oncomine BRCA Research Assay, and Oncomine Immune Response Research Assay Chef-ready Kits • Guidance added for using the Ion AmpliSeq Comprehensive Cancer Panel as a 2‑primer pool panel with the Ion AmpliSeq

OncoKDM is a web-based platform that turns your raw data into actionable clinical insight. OncoKDM is a powerful tool that addresses NGS, IHC, MSI and TMB data to